Prostaglandin and histamine and why blocking them can cause less flares

General
1

I have been seeing a lot of posts talking about how NSAIDS/antihistmains causing less flaring for people on this em forum and others. I think i found out why. I was looking over some studies on chronic inflammation and found that prostaglandin's/histamine are potent vasodialators. and guess what?? NSAIDS/antihistamins stop this reaction from taking place. to sum things up as simple as i can:

Prostaglandins/histamine cause vasodialation (bad for us with EM)

NSAIDS/Corticosteroids/COX-2 selective inhibitors: these cause prostaglandins not to do there job, thus stopping the vasodialation that they cause. (less flares for most of us)

Anti-histamine: Cause histamine not to do its job, reducing the vasodialation that they cause. (again, less flares for us as an effect)


Some helpful quotes:

Examples of prostaglandin antagonists are:
NSAIDs (inhibit cyclooxygenase)
Corticosteroids (inhibit phospholipase A2 production)
COX-2 selective inhibitors or coxibs
Cyclopentenone prostaglandins may play a role in inhibiting inflammation

[edit]Clinical uses of synthetic prostaglandins:
Synthetic prostaglandins are used:As a vasodilator in severe Raynaud's phenomenon or ischemia of a limb. (this is a key trait of synthetic prostaglandins. if you block there
effects, you help erythromelalgia)

Here is a quote on antihistamins:
Antihistamines suppress the histamine-induced wheal response (swelling) and flare response (vasodilation) by blocking the binding of histamine to its receptors on nerves, vascular smooth muscle, glandular cells, endothelium, and mast cells. They exert a competitive antagonism to histamines.

Refrences:
http://en.wikipedia.org/wiki/Prostaglandin
http://en.wikipedia.org/wiki/Histamine_antagonist

If you think I am wrong, let me know! It just seems very very straight forward and easy to understand. let me know what you guys think :D

2

Hi Will

Know this is an older post but wondering how you are doing.

I have been getting quite a bit of flushing in the ears and face, so was looking at mast cells.

I have also been reading up a bit on this, including:

Aspirin that seems to help with burning...

Mast Cells:

http://ednf.org/sites/default/files/Anne%20Maitland.pdf

(Pages, 15/16/17)


Histamines, food list:

http://www.histamineintolerance.org.uk/about/the-food-diary/the-food-list

I wonder how much of this is Mast Cell Disorder related? I might look at the effects when using Second Gen H1 & some H2 anti-histamines to see if they have any effect on my burning feet and random facial dry flushing.